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Crystal structure
PDB 6KDY — human IDH3 αβ heterodimer with NAD⁺ bound, Sun P et al., J Biol Chem 2019, PMID:31515270. (NAD⁺-bound form; note the pseudo-allosteric site that blocks activator binding.)
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Mechanism — hydride + decarboxylation
Gonçalves S, Miller SP, Carrondo MA, et al., Biochemistry 2012, PMID:22891681 — induced fit and the catalytic mechanism: hydride transfer to NAD⁺ (oxalosuccinate), then metal-assisted oxidative decarboxylation to α-KG + CO₂.
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Sequence
Human IDH3A UniProt P50213 · IDH3B UniProt O43837 · IDH3G UniProt P51553 · NCBI Gene 3419 (IDH3A)
› Backbones and ligand poses are taken directly from the listed PDB entries,
superposed into one common frame. Where no crystalline state exists for a step
(e.g., isocitrate approach, CO₂ release), the pose is drawn schematically and
labeled as such in the narration.