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Crystal structure
PDB 2DFD — human mitochondrial MDH2 with malate analog (LMR) and NAD⁺ in the ternary complex (SGC; crystallographic consortium).
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Mechanism — hydride transfer
Chapman AD et al., J Mol Biol 1999, PMID:10075524 — structural basis of substrate specificity in malate dehydrogenases: His general base, hydride transfer to nicotinamide C4.
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Sequence
Human MDH2 (mitochondrial) UniProt P40926 · NCBI Gene 4191
› Backbones and ligand poses are taken directly from the listed PDB entries,
superposed into one common frame. Where no crystalline state exists for a step
(e.g., oxaloacetate release, NADH formation), the pose is drawn schematically and
labeled as such in the narration.