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Crystal structure
PDB 1ZOY — porcine heart mitochondrial Complex II (succinate:ubiquinone oxidoreductase), 2.4 Å, Sun F et al., Cell 2005, PMID:15989954. Flavoprotein (Fp) subunit with covalently bound FAD shown here.
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Mechanism — FAD oxidation
Mäkelä KA et al., Biochem Soc Trans 2014, PMID:25342163 — succinate dehydrogenase (SDH) and the covalent 8α-N3-histidyl-FAD linkage; catalysis via His base and hydride transfer to N5, electrons relayed through Fe-S clusters to ubiquinone.
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Sequence
Pig SDHA (flavoprotein) UniProt Q0QF01 · SDHB (iron-sulfur) UniProt Q007T0 · NCBI Gene 396677 (SDHA)
› Backbones and ligand poses are taken directly from the listed PDB entries,
superposed into one common frame. Where no crystalline state exists for a step
(e.g., succinate approach, fumarate release), the pose is drawn schematically and
labeled as such in the narration.